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CALSCALE:GREGORIAN
X-WR-CALNAME:Schmidt Center - MIT EECS Colloquium\, featuring Ben Raphael (
 Princeton University)
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260521T112046Z
UID:tag:localist.com\,2008:EventInstance_51142914432157
DTSTART:20251103T210000Z
DTEND:20251103T220000Z
DESCRIPTION:Please note that due to travel issues\, this event has been pos
 tponed. We hope to reschedule but do not have details at this moment. We l
 ook forward to seeing you at a future Schmidt Center event!\n\n \n\nSchmid
 t Center - MIT EECS Colloquium: Integrative inference of tissue architectu
 re across space\, time\, and modality by Ben Raphael\n\n‍Monday\, Novemb
 er 3\, 2025\n\n \n\n4:00 - 5:00 pm (refreshments at 3:30 pm)\n\nBroad Audi
 torium (Merkin building\, 415 Main St.)\n\n✍️ Learn more\n\n \n\nPleas
 e join us for a colloquium featuring Ben Raphael\, Graduate Class of 1991 
 Professor of Computer Science\, Princeton University\, on Integrative infe
 rence of tissue architecture across space\, time\, and modality.\n\n \n\nT
 his colloquium is part of a series hosted jointly by the Eric and Wendy Sc
 hmidt Center at the Broad Institute and the Department of Electrical Engin
 eering and Computer Science at MIT. Ben's colloquium will run from 4:00-5:
 00 pm with refreshments served at 3:30 pm.\n\n \n\nThe colloquium will be 
 held at the Broad Institute Auditorium (415 Main St) as well as virtually 
 via YouTube Livestream: broad.io/ewsc. \n\n \n\nIf you do not have a Broad
  badge\, please show up at the 415 Main Street entrance 10 minutes prior t
 o the event to be escorted to the talk.\n\n \n\nLearn more and register he
 re.\n\n \n\nQuestions? Email Amanda Ogden at aogden@broadinstitute.org. \n
 \n \n\nAbstract: \n\nThe spatial organization of tissues is essential to t
 heir biological function. Recent spatialomics technologies measure mRNA\, 
 protein\, metabolite\, and other modalities at thousands of locations with
 in tissue sections\, revealing spatial patterns of cell types and molecula
 r activity. However\, current datasets are often sparse and incomplete due
  to technological and cost constraints. I will present machine learning ap
 proaches to overcome this sparsity by modeling the latent geometry of indi
 vidual tissue slices and by integrating measurements across multiple modal
 ities over space and time. These approaches utilize deep neural networks a
 nd novel formulations of low-rank optimal transport. We apply the resultin
 g methods to analyze spatial variation in cell types and gene expression i
 n normal tissues\, derive gene expression gradients within tumor microenvi
 ronments\, reconstruct three-dimensional tissue architecture across modali
 ties\,and describe spatiotemporal changes in expression during organismal 
 development.
GEO:42.362878;-71.088727
LOCATION:Broad Institute\, Broad Auditorium
SUMMARY:Schmidt Center - MIT EECS Colloquium\, featuring Ben Raphael (Princ
 eton University)
URL;VALUE=URI:https://events.broadinstitute.org/event/schmidt-center-mit-ee
 cs-colloquium-featuring-ben-raphael-princeton-university
CATEGORIES:Talks
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