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Models, Inference & Algorithms (MIA) Meeting

Wednesday, November 19, 2025 9:00am to 12:00pm EST

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Please join us on Wednesday, November 19Β for our MIA meeting featuring Nicholas F. PolizziΒ (Harvard Medical School)!

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🎀 Predicting small-molecule binding sites in proteins using the pair representation of AlphaFold2 

πŸ’¬ Nicholas F. Polizzi

🏫 Harvard Medical School

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Hosted by the Eric and Wendy Schmidt Center, the MIA Initiative (Models, Inference & Algorithms) supports learning and collaboration across the interface of biology and medicine with mathematics, statistics, machine learning, and computer science. We bring together scientists every Wednesday in Acadia (Broad Institute – 75 Ames St., M1) and virtually. A primer starts at 9:00 am, followed by a seminar and discussion at 10:00 am and 10:50 am, respectively.

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πŸ’Œ Join our mailing list for Zoom links: bit.ly/MIACastΒ 

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πŸ§‘β€πŸ« Read the abstracts: broad.io/MIAΒ 

πŸ“Ί Watch previous talks: broad.io/MIAPlaylistΒ 

πŸ—“οΈ View our calendar: broad.io/mia-calendarΒ 

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❓ Ask questions: mia-team@broadinstitute.orgΒ 

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***

πŸ‚ Fall 2025 Schedule β˜•

All events are held in Acadia (75 Ames St., M1) and virtually, unless noted otherwise

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πŸ“… Wednesday, September 24

πŸ“Ί Watch the recorded talks

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βž• Add to calendar

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🎀 Primer, 9:00 am: Infrastructure and modeling challenges in single-cell omics

πŸ’¬ Davide D'Ascenzo

🏫 Polytechnic University of Turin

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🎀 Seminar, 10:00 am: When more isn’t better: rethinking scale in single-cell foundation models

πŸ’¬ Lorin Crawford

🏫 Microsoft Research New England (MSR)

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πŸ“… Friday, October 3

Co-hosted with IDMP

πŸ“Ί Watch the recorded talks

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βž• Add to calendar

πŸ“Broad Auditorium – 415 Main St.

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🎀 Primer, 9:00 am: From Sequence to Structure: Fundamentals of Protein Sequence and Structure Analysis

πŸ’¬ Sooyoung Cha

🏫 Seoul National University

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🎀 Seminar, 10:00 am: Exploring the Protein Universe via Highly Accurate Structural Predictions

πŸ’¬ Martin Steinegger

🏫 Seoul National University

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πŸ“… Wednesday, October 8

βž• Add to calendar

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🎀 Primer, 9:00 am: Ultra-secure computing with homomorphic encryption for genome privacy

πŸ’¬ Jacob BlindenbachΒ 

🏫 Columbia University

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🎀 Seminar, 10:00 am: Privacy-Preserving Approaches to Knowledge Discovery in Biomedicine

πŸ’¬ Gamze GursoyΒ 

🏫 Columbia University

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πŸ“… Friday, October 17

πŸŽ‰ MIA 10-Year Anniversary Celebration

πŸ“Ί Watch Caroline’s opening remarks

πŸ“Ί Watch the MIA overview: reflecting on the past 10 years of MIA

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βž• Add to calendar

✍️ Register here

πŸ“Broad Institute – 300 Binney St. (2110 - Charles)

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πŸ“ Agenda:

9:30 - 10:00 am: Welcome, breakfast

10:00 - 11:00 am: Panel discussion

11:00 - 11:30 am: Lightning talks from Tavor Baharav (Schmidt Center, Broad Institute) and Jiaqi Zhang (Schmidt Center, Broad Institute), networking

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πŸ‘©β€πŸ”¬ Panelists:

πŸ’¬ Alex BloemendalΒ 

🏫 Broad Institute (MIA co-founder and co-chair)

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πŸ’¬ Aleksandrina Goeva

🏫 University of Toronto

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πŸ’¬ Aviv RegevΒ 

🏫 Genentech

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πŸ’¬ Gevorg GrigoryanΒ 

🏫 Generate:Biomedicines

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πŸ“… Wednesday, October 22

βž• Add to calendar

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🎀 First talk, 9:00 am: AI Agents for Biomedical Discovery: Specialized Builds and General Methods

πŸ’¬ Hanchen Wang

🏫 Stanford AI Lab, Genentech

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🎀 Second talk, 10:00 am: A General-Purpose Biomedical AI Agent

πŸ’¬ Kexin HuangΒ 

🏫 Stanford Computer Science

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πŸ“… Wednesday, October 29

βž• Add to calendar

πŸ“Ί Watch the recorded talks

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🎀 Primer, 9:00 am: Inferring transcription factor binding from base-pair level chromatin accessibility using deep learning contribution scores

πŸ’¬ Gregory Andrews

🏫 UMass Chan Medical School

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🎀 Seminar, 10:00 am: Programmatic design and editing of cis-regulatory elements using deep learning

πŸ’¬ Jacob Schreiber

🏫 UMass Chan Medical School

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πŸ“… Wednesday, November 5

βž• Add to calendar

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🎀 Primer, 9:00 am: Permutation Enhances the Rigor of Genomics Data Analysis 

πŸ’¬ Jingyi Jessica Li

🏫 Fred Hutchinson Cancer Center

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🎀 Seminar, 10:00 am: mcRigor: a statistical method to enhance the rigor of metacell partitioning in single-cell data analysis

πŸ’¬ Pan Liu

🏫 Fred Hutchinson Cancer Center

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πŸ“… Wednesday, November 19

βž• Add to calendar

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🎀 Predicting small-molecule binding sites in proteins using the pair representation of AlphaFold2 

πŸ’¬ Nicholas F. Polizzi

🏫 Harvard Medical School

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πŸ“… Wednesday, December 10

βž• Add to calendar

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🎀 Artifacts: Fact and Fiction 

πŸ’¬ Aziz Al'Khafaji

🏫 Broad Institute

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**If you do not have a Broad badge, please arrive at the 75 Ames Street entrance 10 minutes early with an ID to check in with security. We will escort folks up at 8:55 am and 9:55 am; please email mia-team@broadinstitute.org if you arrive outside of these times.